Ama Moor Vicky Jocelyne,Pieme Constant Anatole, Biapa Nya Cabral Prosper, Ikomey Georges, Okomo Cecile,Nkeck Jan Rene and Ngogang Yonkeu Jeanne
University of Yaounde, Cameroon
University of Dschang, Cameroon
Scientific Tracks Abstracts: Med Chem
Background & Aim: Spirulina platensis is traditionally used as a food supplement
with a potential strengthening of the immune system, inhibition of the replication
of some viruses, and lipid-lowering. The aim of this study was to determine its
anti-inflammatory, immunologic, and anti-oxidative effects in HIV patients on
antiretroviral therapy (ART).
Methods: We performed a clinical trial on 62 HIV patients on ART (Tenofovir-
Lamivudine-Efavirenz) divided into two groups. Group I supplemented with 10
grams of Spirulina platensis daily, and group II receiving dietary advices. Participants
were followed for six months, from December 2015 to June 2016. Each group were
sampled for CD4-count, viral load, serum levels of interleukins 6 and 8, TNFα and
oxidative markers (malondialdehyde, FRAP, catalase, total peroxides, superoxide
dismutase, glutathione peroxidase, reduced glutathione) at the beginning (T0) and
the end of the trail (T1). Ethical clearance was obtained from the national committee
on ethics of human health research in Cameroon (Ref 2016/01/699/CE/CNERSH/
SP). Statistical analysis was performed using the software SPSS 18.0. The threshold
of significance was set at 0.05.
Results: Mean ages of participants were 35±8 and 37±7 respectively for group I and
II. We observed a significant decrease in viral load in patients receiving Spirulina
comparing at T0 and T1 (p=0.04), and as compared to participants in group II
(p=0.01). CD4-court was unchanged. There was a significant reduction of IL8 and
TNFα levels in both groups but not statistically related to the supplementation. The
levels of pro-oxidative markers have significantly decreased and antioxidant levels
significantly increased in group I, compared to group II.
Conclusion: Daily supplementation of Spirulina platensis could improve the immune
status of HIV patients on ART, and decrease inflammatory and pro-oxidant levels.
Ama Moor Vicky Jocelyne is a Medical Doctor since 17 years; specialized in Clinical Pathology since 10 years and received her PhD degree in the year 2018 from University of Yaounde in Cameroon. She is working on Dyslipidemia Occurrence in Cameroon, and has interest on Spirulina platensis a microalgae with a lot property. She is Associate Professor in the Department of Biochemistry, Faculty of Medicine and Biomedical Science at the University of Yaounde. She has published more than 45 papers in reputed journals.
E-mail: movicky@yahoo.fr
Medicinal Chemistry received 6627 citations as per Google Scholar report
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