Emerging nano-pharmaceuticals and cancer therapy

13^th Asia-Pacific Oncologists Annual Meeting

October 17-19, 2016 Kuala Lumpur, Malaysia

Md Ezharul Hoque Chowdhury

Jeffrey Cheah School of Medicine and Health Sciences - Monash University, Malaysia

Posters & Accepted Abstracts: J Cancer Sci Ther

Abstract :

Treatment of a human disease in the genetic level either providing a cell with a functional gene or a nucleic acid sequence to precisely silence a harmful gene is a powerful approach to revolutionize the clinical medicine. Despite existence of both genetically engineered viral vectors and synthetically designed lipid- or polymer-based nano-carriers, an ideal delivery system in terms of safety and efficacy is still lacking. We have recently developed a highly efficient gene delivery device based on carbonate apatite nano-crystals having high affinity for siRNA or drugs (through electrostatic interactions) but fast dissolution kinetics for effective release of the payloads during vesicular acidification. Moreover, for cell-specific and more efficient transgene delivery, we successfully assembled a desirable cell-recognizable protein and a highly hydrophilic protein onto the crystal surfaces, thereby creating dual surface properties, one facilitating cell-specific delivery and the other blocking non-specific interactions. A delicate control on manipulation of particle diameter additionally helps us passively to target the nanoparticles to the tumor via EPR effect. As a result, intravenous delivery of nanoparticles-associated siRNAs targeting growth factor receptors and anti-apoptotic genes resulted in significant reduction in tumor regression in a syngeneic mouse model of breast cancer and remarkably sensitized the tumor to the chemotherapy drugs, thus shedding light on their potential applications in treating cancer in human patients.

Biography :

Email: md.ezharul.hoque@monash.edu