Engineering of multi-functional composite nano-particles to address anti-microbial resistance using EHDA particle technology

7^th Annual Congress on Materials Research and Technology

February 20-21, 2017 Berlin, Germany

Suleman Ramzan

De Montfort University, UK

Posters & Accepted Abstracts: J Material Sci Eng

Abstract :

Antibiotics are key pharmaceuticals, which have significantly improved the health and wellbeing of the mass population globally. Drug development in this area has led to significant reduction of numerous infectious diseases including tuberculosis (TB). In recent years, bacterial resistance to antibiotics has led to the need to develop novel strategies to target and kill these microbes, and the production of antibiotic degrading enzymes is the most common form of antibiotic resistance (ABR). A reason for this is due to the overuse and misuse of antibiotics in the USA in the last year alone; 160 million antibiotic prescriptions were supplied. Many novel methods and strategies have been developed to kill bacteria; one such technique involves the use of nanoparticles. The advantages of nano-based systems are enhanced bioavailability and better target-specificity. Furthermore, the combination of nanoparticles (NPs) alongside established antibiotics makes them more lethal for microorganisms. Therefore, there is a need to develop novel strategies, which combine two or more proven anti-bacterial methods, while at the same time dosage form safety is maintained. In this work several types of metallic NP`s were synthesized (gold and silver, using method) and characterized (SEM, TEM, XRD and UV). The NPs were then co-delivered in a PLGA polymer particle system (size ~nm). This was achieved using the electrohydrodynamic atomization (EHDA) process making use of acetone and di chloromethane as base carrier solvents (flow rates=5-50 �¼L min-1, applied voltage=0-30 kV, nozzle diameter=500 �¼m). Additional formulations were used to prepare similar particle systems using amoxicillin (5 w/w% of PLGA carrier). The findings indicate an ambient temperature process to engineer multi-functional composite systems in a single step with the active intact. Particle size was easily varied using process parameters (flow rate and applied voltage) providing options to control drug and NP loading in PLGA matrix systems.

Biography :

Suleman Ramzan is pursuing his PhD in Advanced Drug Delivery Group (specializing in EHDA systems) and his expertise is in Nanotechnology. He completed his BSc Honors in Pharmaceutical and Cosmetic Sciences at De Montfort University.

Email: sulemanramzan@gmail.com