Evaluation of delivery route efficiency of microwave synthesized nanostructures of hap: An artificial bone material

2^nd International Conference and Exhibition on Materials Science & Engineering

October 07-09, 2013 Hampton Inn Tropicana, Las Vegas, NV, USA

Vijay Kumar Mishra, Somanshu Banerjee, Shyam Bahadur Rai, Chandra Mohini Chaturvedi, Om Parkash and Devendra Kumar

Accepted Abstracts: J Material Sci

Abstract :

Skeleton gives basic infrastructural platform for the development of soft tissues in mammals. Bones play key role in any type of motion and make body enable for load bearing. Scientists are attracted towards some synthetic bone materials due to lack of bone fractures in road accidents, need of total hip replacement, total knee replacement and several other bone diseases like osteoporosis in old ages or in pregnancy, osteomalacia, osteogenesis imperfecta, osteochondroma. Hydroxyapatite Ca 10 (PO 4 ) 6 (OH) 2 : (HAp) is found to be most useful ceramic material for artificial bone and teeth due to excellent bioactivity, biocompatibility and stability. It is also reported that nano-HAp is able to enhance osteoblast activities, such as cell adhesion, proliferation, differentiation, and mineralization as compared with micro-sized HAp. The natural bone exhibits the natural nanoparticles of HAp crystals with rod-like or needle-like shapes, forming the composite with polymeric matrix of collagen type I. The range of the particle size of natural HAp nanostructures formed in physiological conditions in human is 10-80 nm. Therefore we have developed several nanostructures such as nanorods, nanostrips, nanocapsules of HAp. Evaluation of different nanostructured HAp delivery at target specific oesteogenic sites may be possible through most abundant circulatory medium blood. This study is necessary to elucidate the most efficient delivery route of HAp to the target site through blood as well as to check the toxicity of the delivered material HAp. To evaluate the most efficient delivery route for HAp nanorods, the vibrational spectroscopy is employed and fruitful results have been found.

Biography :

Vijay Kumar Mishra is a research scholar in Department of Physics, Banaras Hindu University and Department of Ceramic Engineering, Indian Institute of Technology-Banaras Hindu University, India. He is currently working on synthesis of different nanaostructures of hydroxyapatite and its fictionalizations. Along with hydroxyapatite he is also working on borosilicate glasses with an expert group in University of Lucknow, Lucknow. He has published three papers in reputed international journals such as Journal of the American Ceramic Society, Phase Transitions: A multinational Journal etc. One paper is communicated in Materials Science and Engineering C.