Evaluation of Sterotex HM in optimization of curcumin loaded solid lipid nanoparticles

2^nd International Conference and Exhibition on Pharmaceutical Regulatory Affairs

November 23-24, 2012 Hyderabad International Convention Centre, India

S. Karthik

Accepted Abstracts: Pharmaceut Reg Affairs

Abstract :

Bioavailability issues are one of the challenging tasks for the formulation of BCS class II and class IV drugs. Many newer excipients and technologies have been employed to attain enhanced bioavailability. In this line, application of lipids for bioavailability enhancement of poor soluble drugs is promising. The present investigation was focussed to evaluate Sterotex HM in optimization of Solid lipid nanoparticles (SLN) solid lipid nanoparticles. Curcumin was selected as model drug for the optimization of SLN. 23 factorial designs were adopted and eight formulations were prepared with two levels of lipid, surfactant and co-surfactant. High shear homogenization method was used to prepare curcumin SLN. Prepared formulations were subjected to various evaluations such as morphology, particle size, zeta potential and drug content. The particle size and zeta potential were used as the response for the optimization of prepared formulations using design expert. Among all the formulations, SLN prepared using ration of 1:2:0.2 lipid: surfactant: co-surfactant (CU F3) was found to be better with particle size, PDI, zeta potential and drug content of 101.4nm, 0.033, -42.8mV and 42.5% respectively. The results reveal that the low lipid concentration with high surfactant will be useful for achieving uniform nanoparticles. Further, the in vivo studies can be performed to claim the potency of the curcumin SLN.

Biography :

I am S.Vidya pursuing 1st M.Pharmacy at JSS College of Pharmacy, Mysore. I had pursued my bachelor degree in pharmacy from JSS College of Pharmacy, Ooty. I attended few international conferences and seminars