Evaluation of the Anti RT HIV-1 and Anti-candidal properties of Heteropterys brachiata

3^rd World Congress on Complementary & Alternative Medicine

August 23-24,2021 | Webinar

Getsemani Sinai Villanueva Amador

National Autonomous University of Mexico

Scientific Tracks Abstracts: Altern Integr Med

Abstract :

Despite efforts to control and prevent new cases of HIV infection, the prevalence of HIV/AIDS patients has not shown an evident decrease. Opportunistic infections, like oral fungal infections related to AIDS are the most prevalent worldwide.Having a drug that has a double pharmacological effect, anti RT HIV-1 and anti-candidal, would represent a better therapeutic option. For these reasons, the present study evaluated the anti-candidial and anti RT HIV-1 properties of the methanolic extract of plant species Heteropterys brachiata (Malpighiaceae) (HbMeOH). Likewise, it was chemically analyzed to identify the main secondary metabolites. HbMeOH inhibition on RT HIV-1 was obtained using the Lenti RT® Activity Assay kit (Cavidi Tech). At a concentration of 1% HbMeOH, the inhibition of RT was 38.8 ± 1.5, at 0.1% it was 25.8 ± 0.6 and at 0.01% it was 12.5 ± 1.0.Candida albicans ATCC® 90028 strains were shown to display sensitivity to HbMeOH. According to the CLSI, if the inhibition percentage is greater than 50%, it is considered to be sensitive. The lowest sensitive, 61%, was at 2.5 mg/ ml concentration and the highest inhibition, 98%, was at 10 mg/ml. This study is the fi rst report of the presence of alkaloids, saponins and tannins metabolites in HbMeOH. Results indicate that the methanolic extract of Heteropterys brachiata has anti RT HIV-1 and anti-candidal properties; in the future it will be necessary to carry out studies specifi cally to determine the target of action. Therefore, it can be considered as a future candidate for AIDS therapy.

Biography :

Getsemaní Sinaí Villanueva Amador is a Biologist and has completed her MSc from Universidad Nacional Autónoma de México (UNAM, National Autonomous University of Mexico). Her professional experiences comprise working as a researcher in Phytochemistry, Molecular Biology and Mycology. She is also a professor of Botany in the Biology career at Science Faculty, at UNAM. She has published 3 papers since 2020.