Exploring the antituberculosis potential of Schiff-base transition metal complexes: Synthesis and characterization of copper (II) and cobalt (II) complexes of 5-(substituted-salicylidene) amino pyridine

5^th International Conference on Organic and Inorganic Chemistry

July 12-13, 2018 | Paris, France

C U Dueke-Eze, T M Fasina, O B Familoni, A O Coker and J M Mphalele

University of Lagos, Nigeria
College of Medicine of the University of Lagos, Nigeria
University of South Africa, South Africa

Posters & Accepted Abstracts: J Chemical Sci

Abstract :

Treatment of tuberculosis (TB) still remains an important and challenging problem because of a combination of factors including increasing the number of multi-drug resistance to the existing tuberculosis drugs and comorbidity of TB with HIV. The World Health Organization recently reported TB as one of the leading cause of death from infectious disease especially in Africa. Discovery of new compounds with anti-tuberculosis (anti-TB) effect and possibly with mechanism of action different from those of well-known TB drugs is highly desirable. Schiff-bases and their metal complexes represent major investigational compounds. The Schiff-bases were obtained by the condensation reaction of salicylaldehyde with 2 (L1-L4) and 4-aminopyridine (L4-L7). They were reacted with CuCl2.H2O and CoCl2.6H2O to form Cu (II) and Co (II) complexes. 1H, 13C NMR, IR, electronic absorption and elemental analysis confirm the formation of the ligands. The metal complexes were also characterized on the basis of various spectroscopic techniques. The compounds were screened for their anti-TB activity using the proportion method and isoniazid (INH) as a reference compound. The complexes showed enhanced in-vitro anti-tuberculosis activity against Mycobacterium tuberculosis H37RV compared to the free ligands and the reference compound (INH). Co (II) complex containing the nitro substituent exhibited significant anti-TB activity with an MIC of 0.05 �¼g/mL, the results demonstrate that compounds with imine group and metal ion can display strong anti-TB activity making them suitable as lead compound in the development of new TB drugs.