Expression of androgen receptor and cyclooxygenase-2 in the vesicular glands of castrated and intact goat

International Conference on Histochemistry & Cell Biology

September 14-15, 2016 Phoenix, USA

Mahmoud Abdelghaffar Emam

Benha University, Egypt

Posters & Accepted Abstracts: J Cytol Histol

Abstract :

This study was conducted to demonstrate the effect of castration on the structure of vesicular glands of the Egyptian Nubian (Zaraibi) goat. Vesicular glands of castrated (n=4) and intact (n=6) goat were used for histological and immunohistochemical evaluations. In this study, we report the difference in cell specific expression of androgen receptor (AR) and cyclooxygenase-2 (COX-2) in the vesicular glands of castrated and intact goats. In both castrated and intact goats, the present study revealed no immunopositive cells for AR or COX-2 in the fibromuscular stroma meanwhile, AR and COX-2 containing immunoreactive cells were restricted only to the epithelium of the secretory acini of the vesicular gland. Such finding suggests androgen and COX-2 as important regulators for the growth and secretory activity of epithelial cells in the vesicular gland of goats. Overall, the vesicular gland of castrated goats showed significantly (P<0.05) lower AR and COX-2 immunoexpression than intact goats indicating that both AR and COX-2 are androgen dependent.

Biography :

Email: Mahmoud.hussein@fvtm.bu.edu.eg