Tahrir N N Aldelaimi
Accepted Abstracts: J Cancer Sci Ther
A number of etiologic factors have been implicated in the development of oral squamous cell carcinoma (OSCC). The overall survival rate of is low; largely because of the propensity of some tumors to disseminate via the lymphatic and the finding of lymph node involvement is one of the strongest indications of poor prognosis. Twenty five patients including 11 females and 14 males with Oral Squamous cell carcinoma who have been treated surgically at Maxillofacial Surgery Unit, Surgical Specialties Hospital, Medical City. Patients was examined and evaluated clinically and prepared for surgeries. Biopsy specimens sent to Histopathological examination for confirmation of diagnosis, another sections of block of biopsy undergone immunohistochemical study for evaluation of expression of Cytokeratin CK-HMW and Epithelial Membrane Antigen EMA. CK-HMW expression was found higher in 60-69 years old age group, CK-HMW expression was observed in OSCC of WD grade in 3 (12%), 1(4%) and 3 (12%) as strong, mild and moderated expression respectively and most expression was found in stage II including 4 (16%), 6 (24%) and 2 (8%) for strong, moderate and mild expression respectively. EMA expression in OSCC was found in 22 (68%) and higher expression was found in 60-69 years old age group, EMA expression was observed in OSCC of WD grade in 3 (12%), 1(4%) and 6 (24%) as strong, mild and moderated expression respectively and most expression was found in stage II including 4 (16%), 4 (16%) and 7( 28%) as strong, moderate and mild expression respectively. The results provide an extended knowledge about the role of monoclonal antibodies expression patterns in OSCC, increased expressions of EMA & CK-HMW reflect the invasive properties and malignant potential of OSCC.
Cancer Science & Therapy received 5332 citations as per Google Scholar report
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