Kasi Pitchumani and Basuvaraj Suresh Kumar
Madurai Kamaraj University, India
Posters & Accepted Abstracts: Med chem
Zeolitic imidazolium framework (ZIF-8) materials are crystalline tri-dimensional networks consisting of metal ions or metal clusters bridged tetrahedrally via the imidazole linker, exhibiting high microporosity, large surface area, thermal and chemical stabilities with characteristics of both MOFs (e.g. easily tunable pores and cavities) and zeolites (e.g. high aqueous stability), which render them as excellent platforms for drug delivery studies. Herein, a facile methodology is developed to fabricate magnetic, microporous and pH-responsive drug delivery vehicles based on iron oxide and zeolitic imidazolium framework (Fe3O4 and ZIF-8) structures to form hybrid magnetic ZIF-8 nanoparticles (Fe3O4@ZIF-8 NPs) to entrap the anti-cancer drug â??berberine (Bn)â?, a naturally occurring plant alkaloid which is isolated from Mahonia leschenaultti roots. The synthesized Fe3O4@ZIF-8 NPs are extensively characterized by powder XRD, SEM and HR-TEM analyses. This Bnencapsulated Fe3O4@ZIF-8 NPs display high drug loading capacity (4.8 mg /10 mg), pH sensitive release profile and magnetic response. Controlled berberine release experiments are carried out at pH values of 7.4, 6.2 and 5.0, and release at pH 5.0 is 2.5 times as fast as that at pH 7.4 and 1.5 times fast as that of pH 6.2. MTT assay and confocal microscopic images are used to evaluate the cytotoxicity of Bn and Bn loaded Fe3O4@ZIF-8 NPs in MCF-7 cell lines, which indicate lower cytotoxicity towards MCF-7 cells. In addition, results of other controlled drug delivery studies from our group, i.e., silica nano-assembled capsules for delivering doxorubicin and microporous carbon for delivering berberine will also be presented.
Email: pit12399@yahoo.com
Medicinal Chemistry received 6627 citations as per Google Scholar report
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