Fibrinogen and Fibrin Degradation Products Levels in Cardiopulmonary Bypass with Mild- Hypothermia versus Normothermia

World Congress on Heart

April 25-26, 2022 | Webinar

Motahareh Ghodrati

Faculty of Qom University of Medical Sciences, Iran

Scientific Tracks Abstracts: jigc

Abstract :

Background: Coagulation cascades are activated during Cardiopulmonary Bypass (CPB) and their proper monitoring and maintenance determine the outcomes of operation to a big extent. Here, we assessed serum fibrinogen and Fibrin Degradation Products (FDP) in adult patients undergoing CABG with using CPB, either with hypothermia or normothermia. Materials and Methods: In a cross-sectional study, 80 adult patients’ candidate for elective CABG were randomly assigned into two groups: hypothermia and normothermia to assess fibrinogen and FDP, perioperatively. Results: Patients included 32 men (80%) in the hypothermia group and 26 men (60%) in the normothermia with the mean age of 61.43 ± 12.64 years. The mean temperature in the hypothermia group was 32.33 ± 1.44 and 35.33 ± 0.71 in the normothermic group. Differences in fibrinogen levels between the two groups were not significant (Fib before CPB, P=0.893, and Fib afte declamping, P=0.057). The serum level of FDP before and during CPB was not significantly different in hypothermia and normothermia groups (P=0.412, P=0.778, respectively). Conclusion: During cardiac surgery in hypothermia and normothermia conditions rate of fibrinogen decreased 25% after declamping in each group; this decrease seems to be due to hemodilution. FDP levels were similar in both groups
Recent Publications:
1. "Evaluation of the safety and efficacy of low dose propofol infusion compared to midazolam during colonoscopy and retrograde cholangiopancreatography" Knowledge & Health journal. Spring 2013, Volume 8, Number 1.
2. "Fibrinogen and Fibrin Degradation Products’ Levels in Cardiopulmonary Bypass with Mild-Hypothermia versus Normothermia" Journal of Cellular & Molecular Anesthesia, Vol. 5 No. 3 (2020), 19 October 2020
3. "Pulmonary Disorder in a Patient Recovering from Coronavirus Disease 2019 in Cardiac Surgery: Case Report and Review". Int J Cardiovasc Res 9:6. October 2020
4. "Comparing Two Kinds of Prime Solution between Ringer/Albumin and Ringer Lactate/Gelatin for Patients Undergoing Cardiopulmonary Bypass". Int J Cardiovasc Res 2021 10:5.
5. sharififardd F, nazari N, Asayesh H, Ghanbari Afra L, goudarzi rad M, shakeri M, et al . Evaluation of psychological disorders in nurses facing patients with colloid 19 in 2020. Qom Univ Med Sci J. 2021; 15 (2)

Biography :

I have completed my M.S in Cardiovascular Science at the age of 30 years from Shiraz University of Medical Sciences, Iran. I am working as a Faculty of Anesthesia department of Qom University of Medical Sciences, Iran. I have 5 publications and have 6 lectures in international congrees. Also, I have been serving as a reviewer of several reputed journals.