Fish oil as an adjuvant to chemotherapeutic treatment in experimentally induced colon carcinogenesis

9^th Indo Global Summit on Cancer Therapy

November 02-04, 2015 Hyderabad, India

Navneet Agnihotri and Isha Rani

Punjab University, India

Posters-Accepted Abstracts: J Cancer Sci Ther

Abstract :

5-Fluorouracil (5-FU) is used for the treatment of colorectal cancer but has low therapeutic response rate and severe side effects. Recently fish oil (FO) rich in n-3 PUFAs has been reported to chemo-sensitize tumor cells to anticancer drugs, thereby, increasing their efficacy. Therefore, we decided to evaluate the effect of fish oil supplementation on 5-FU mediated cytotoxicity and side effects in experimental colon cancer. Colon cancer was induced by N, N�-dimethyl hydrazine dihydrochloride/dextran sodium sulphate (DMH/DSS) treatment. We observed not only a significant increase in survival rate and decrease in tumor volume count but also amelioration of side effects. Moreover, the combination dosage significantly augmented apoptosis, DNA damage and inhibition of cell cycle progression by 5-FU. It is hypothesized that n-3 PUFAs are incorporated in membrane and alter not only its structure, transport but also several signaling pathways and proteins implicated in tumor progression. Our observations indicate that there was an increase in the levels of n-3PUFAs in tumor tissue. Moreover, there was an altered drug distribution with more drugs being targeted to the tumor. To conclude, this preclinical study demonstrates that FO may prove as a powerful adjuvant for the chemotherapeutic regimens by chemo sensitization of cancer cells.

Biography :

Email: singlaisha8@gmail.com agnihotri.navneet@gmail.com