Flocatera (Flavonoids as cancer preventive therapy): The usage of flavonoids in Ketepeng Cina (Cassia alata L.) as an anti-cancer through anti-inflammatory mechanism

8^th Euro Global Summit on Cancer Therapy

November 03-05, 2015 Valencia, Spain

Lissa Novia Permatasari, Nur Aprilianita Pratama, Leny Silviana Farida, Suryaning Rasyidah, Husnur Rofiqoh, Manik Retno Wahyunitisari, M Kes and Nila Kurniasari

Airlangga University School of Medicine, Indonesia

Posters-Accepted Abstracts: J Cancer Sci Ther

Abstract :

The highest flavonoid content is in Ketepeng Cina with 26.86 mg/ mL. Flavonoids can act as an inhibitor of pro-inflammatory enzymes, namely COX-2. Excessive expression of COX-2 inhibits apoptosis of tumor cells and increases the level of invasive; while COX-2 inhibitors, which have been declared, can reduce the risk of tumors in the digestive system, breast and bladder. Inflammatory cells secrete cytokines increase the levels of ROS and RNI in premalignant cells. Chronic inflammatory reaction can cause a variety of pathological changes of cells such as fibrosis, angiogenesis aberan and neoplasia. Experimental studies using a completely randomized design, extract 100% Ketepeng Cina obtained from 95% ethanol maceration method. There are 4 groups of samples of experimental animals Musmuculus females. DMBA cancer inducer (Benzophenanthrene) subcutaneously by injection obtained the value of P <0.05 means that there are an influence on each group and each treatment against the onset of inflammatory cells based preparations histopathology breast tissue of mice, the group that shows the degree of non-inflammation were negative control group and Ketepeng Cina extract dose of 750 mg/kg. Severe inflammation degree (23%) contained in the positive control group. Ketepeng Cina extract dose of 750 mg/kg proved effective in preventing inflammation with no inflammation (23%),the dominance of mild inflammation (60%) and inflammatory cell types show the dominance of PMN cells (acute inflammation) by 63%. While the Ketepeng Cina extract dose of 500 mg/kg dominance mild inflammation (70%) and moderate inflammation (30%), inflammatory cell types show the dominance of mononuclear cells (chronic inflammation) by 67%.

Biography :

Email: lissa.novia24@gmail.com