Formulation and evaluation of diclofenac sodium gels using carbopol and hpmc as gelling agents

2^nd International Conference and Exhibition on Pharmaceutical Regulatory Affairs

November 23-24, 2012 Hyderabad International Convention Centre, India

M. Asad Ansari

Accepted Abstracts: Pharmaceut Reg Affairs

Abstract :

The present research has been undertaken with the aim to develop a topical gel formulation of Diclofenac sodium using gelling agents i.e. carbopol and HPMC in different concentration, which would attenuate the gastrointestinal related toxicities associated with oral administration. They were evaluated for physicochemical properties such as homogeneity, grittiness, viscosity, pH, Spreadability, drug content, skin irritancy, in vitro drug release, stability studies. Studies showed that drug release was decrease with increase in gelling agent concentration because polymer concentration increases, viscosity increases. Drug was absorbed from site of application as long as it remains in higher concentration gelling agent in solution form.

Biography :

M. ASAD ANSARI completed B. Pharma in 2011 from Kota College of Pharmacy, Kota (RAJASTHAN.). Presently he is an M. Pharma. (Pharmaceutics) Student in Kota College of Pharmacy, Kota (Rajasthan). ASAD has attended 1 National conference IPC in Ahmedabad (Gujrat). His Research Guide is Dr. M. P. Khinchi is having 15 International Research Articles, 20 International Review Articles and he is Attended 12 National Conferences.