Gupta Shailesh and Kohli Seema
Oriental College of Pharmacy, India
Kala Nikaten Govt. Polytechnique College, India
Posters & Accepted Abstracts: Med chem
Somlata (Sarcostemma acidum) herb is highly used by the rural and tribal people in curing various disorders. The aim of the current investigation is formulation and evaluation of ethosomal novel vesicular carrier bearing S. acidum extract. Ethosome has become an area of research interest in herbal formulation because of it�s enhanced skin permeation and improved entrapment efficiency. S. acidum loaded ethosomal carriers were prepared, optimized and characterized for microscopy, vesicular size, entrapment efficiency, stability and in-vitro release study. The entrapment efficiency of ethosome suspension containing ethanolic extract, formulation FE8 was found to be highest (75.91%) while FE3 formulation showed least entrapment efficiency (66.66%). The entrapment efficiency of formulation containing EAE was observed to be highest for FE8,EAE formulation (74.54%) and least for FE3,EAE (58.87%). In-vivo anti-inflammatory study of optimized ethosomal gel formulation (FEEAE) reviled that percentage inhibition of edema by ethosomal gel containing EAE extract was observed to be -32.13% 9 (at 1 hr.) and 42.03% (at 4 hr.) and it was concluded from the present work that ethosomal gel containing ethyl acetate extract of S. acidum herb can use as a alternative medicine in treatment of inflammation disease.
Email: shailgpharma@gmail.com
Medicinal Chemistry received 6627 citations as per Google Scholar report
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