Formulation and evaluation of pH-sensitive nanoparticles for intestinal - site specific drug delivery system

2^nd International Conference and Exhibition on Pharmaceutical Regulatory Affairs

November 23-24, 2012 Hyderabad International Convention Centre, India

VNSK Varma

Accepted Abstracts: Pharmaceut Reg Affairs

Abstract :

The objective of this study was to develop a novel pH sensitive nanoparticulate system for Intestinal- site specific drug delivery based on natural gums for the Intestinal ulcer application. Esomeprazole magnesium was used as a model drug. Guar gum is used as the polymer for preparation of pH sensitive nanoparticles. Thus formulated nanoparticles are dispersed in a Capsule. The size distribution of the prepared nanoparticles is measured. FT-IR and DSC were made to examine the compatibility between the drug and the polymer. The morphology of the nanoparticles is examined by SEM. Drug content of prepared nanoparticles is performed and the In-vitro dissolution of nanoparticles is evaluated.

Biography :

VNSK Varma has done Bachelors in Pharmacy at NGSMIPS, Mangalore. He is presently pursuing M. Pharmacy in Pharmaceutics stream at JSS college of Pharmacy, JSS University Mysore. He has participated in several international conferences and seminars and made poster presentation in various international &conferences and seminars.