Functionally designed scaffolds for biomedical applications

3^rd International Conference on Medical Physics & Biomedical Engineering

November 07-08, 2016 Barcelona, Spain

Henrique de Amorim Almeida

Polytechnic Institute of Leiria, Portugal

Posters & Accepted Abstracts: J Bioengineer & Biomedical Sci

Abstract :

Tissue engineering represents a new, emerging interdisciplinary field involving combined efforts of biologists, engineers, material scientists and mathematicians towards the development of biological substitutes to restore, maintain, or improve tissue functions. Most strategies in tissue engineering have focused on using biomaterials as scaffolds to direct specific cell types to organize into three-dimensional structures and perform differentiated functions. The three most common strategies which have been adopted for the creation of new tissues are: Self-assembly cells, acellular scaffolds and cell-seeded temporary scaffolds. Scaffolds provide temporary mechanical and vascular support for tissue regeneration while shaping tri-dimensional in-growth tissues. Therefore, scaffolds should be biocompatible, biodegradable with appropriate porosity, pore structure, pore distribution, optimal mechanical and vascular behavior and optimal cell mechano-biological stimulation. The design of optimized scaffolds based on the fundamental knowledge of its macro and microstructure is a relevant topic of current research works. Besides presenting a general overview of current numerical scaffold design methodologies, this presentation also explores the use of biomimetic based designs combined with topological optimization schemes. A brief overview of other numerical research works in the field of scaffold design will also be presented such as the mechanical and vascular prediction of polymer degrading scaffolds.

Biography :

Email: henrique.almeida@ipleiria.pt