Galactofuranose-based compounds as potential inhibitors of GlfT1

11^th Annual Congress on Chemistry

September 12-13, 2018 Singapore

Benice Lyrem Joy S Lim, Completo Gladys Cherisse J, Tabilog Andrew Exequiel S, Allas Mikel Jason D G, Angkico Rowin Christian B, Espejo JaeveeWilliam T, Sumalde Jan Michael C, Joe Maju, Zheng Blake and Lowary Todd L

University of the Philippines-Los Banos, Philippines
De La Salle University, Philippines
University of Alberta, Canada

Posters & Accepted Abstracts: Chem Sci J

Abstract :

The enzyme Galactofuranosyltransferase 1 (GlfT1), initiates the elongation of the Galactan chain of the mycolyl- Arabinogalactan Peptidoglycan (mAGP) complex of the mycobacterial cell wall. mAGP is essential for the microorganismâ??s viability and its Galactan chain backbone is comprised of alternating 5- and 6-linked β-D-Galactofuranose (Galf) units that are not found in humans and thus, enzymes (e.g. GlfT1) involved in its biosynthesis might serve as putative therapeutic targets in diseases such as tuberculosis. Several potential inhibitors resembling the polysaccharide glycan were synthesized and tested against GlfT1.

Biography :

Benice Lyrem Joy S Lim is a MS Chemistry student at the University of the Philippines Los Baños. She works as a Research Associate in the laboratory of Dr. Gladys Cherisse J Completo. Her field of interests involves synthetic and Natural products chemistry.

E-mail: bslim@up.edu.ph