Gelatin-Coated Magnetite Nanoparticles for Drug Delivery System

18^th International Conference and Exhibition on Materials Science and Engineering

May 28-30, 2018 Osaka, Japan

Anuvat Sirivat and Nophawan Paradee

Chulalongkorn University, Thailand King Mongkut′s University of Technology Thonburi, Thailand

Posters & Accepted Abstracts: J Material Sci Eng

Abstract :

Drug delivery is the method of administering a pharmaceutical compound to achieve a therapeutic effect in humans based on the drug safety and efficacy at the targeted therapies. The pharmaceutical agents or drugs of interest are entrapped within, or attached to an organic polymer matrix or inorganic particle. Magnetic nanoparticles (MNPs), one of the inorganic nanoparticles, can be manipulated by external magnetic field to lead it to the target tissue. The therapeutic agents are attached to, or encapsulated within, a magnetic nanoparticle by polymer coating. This work aims to synthesize magnetite nanoparticle (Fe3O4-NP) via the bio-chemical co-precipitation under using gelatin as biomaterial templates for cancer drug carrier. The cancer drug is attached to the Fe3O4-NP through a functional group between the gelatin and the drug. The Fe3O4-NP morphology with and without drug attaching were spherical in the size of 24-28 nm. The magnetization and the electrical conductivity decreased after attaching the drug. However, the gelatin-coated Fe3O4-NP was suitable for cancer drug carrier because it can response to an external magnetic field and provided suspension stability.

Biography :

Anuvat Sirivat obtained B.S. in 1977, M.E. in 1978 followed by Ph.D. in 1983 all in  Mechanical Engineering, from Cornell University, USA, and later  completed a Postdoctoral study  in  Chemical  Engineering  in  1985  from  Johns  Hopkins  University. Currently, he is a Professor of Polymer Engineering at Petroleum and Petrochemical College, Chulalongkorn University, Thailand. He is supported by many Royal Thai Government grants related to Conductive and Electroactive Polymers. His research interests are: conductive and electroactive polymers; rheology, stability, transition, and turbulence of complex fluids; and light scattering.