Gold nanoparticles (GNPs) new synthesis method and modification with novel polyethylene glycol (PEG)-N-acetyl cysteine (NAC) conjugate

European Chemistry Congress

June 16-18, 2016 Rome, Italy

Amal Hwaree Ayoub, Maisa Haj Inebtawi and Seba Jawabry Shadafny

Metallo Therapy ltd., Israel

Posters & Accepted Abstracts: Chem Sci J

Abstract :

In this paper, we describe a new method to synthesize small gold nanoparticles (average diameter of ~3.5 nm). Our method is based on the use of micro emulsion to mediate the reduction process; the micro emulsion guarantees soft reduction process, uniformity of the produced GNPs as well as it controls particles size and shape. In addition, we introduce a novel polyethylene glycol (PEG)-N-acetyl cysteine (NAC) conjugate (PEG-NAC) for surface modification of the GNPs. The new PEG-NAC conjugate attaches the surface of the gold nanoparticles via the thiol group of the NAC and intended to provide GNPs enhanced solubility and improved stability particularly at protein containing solutions. amalay@metallo-therapy.com