Hepatoprotective potential of moralbosteroid against carbon tetrachloride induced hepatotoxicity in Wistar albino rats

4^th World Congress on Cancer Science & Therapy

October 20-22, 2014 DoubleTree by Hilton Hotel Chicago-North Shore Conference Center, USA

Gaurav Gupta and Firoz Anwar

Accepted Abstracts: J Cancer Sci Ther

Abstract :

The present work presented here evaluates the hepatoprotective potential of moralbosteroid, isolated from Morus alba, against carbon tetrachloride induced hepatotoxicity in Wistar albino rats. Hepatoprotective action was estimated by measuring aspartate amino-transferase (AST), alkaline phosphatase (ALP), serum alanine amino-transferase (ALT), total bilirubin (TB), and total protein (TP), including glutathione transferase (GST), glutathione peroxidase (GPx), catalase (CAT), lipid peroxidation (LPO) and superoxide dismutase (SOD). The oral administration of carbon tetrachloride significantly increased the LPO level (13.22±1.59 μM/mg protein) when compared to control. The levels of antioxidant enzymes including CAT, SOD, GPx and GST were decreased significantly (0.38±0.6 nmol/min/ml, 0.89±0.83 U/ml, 3.90±0.91 μmol and 0.05±0.16 U/min/mg protein in testicular tissue) as compared to control animals. Moralbosteroid significantly prevented the marked escalation of serum markers and inhibited the free radical processes by scavenging hydroxyl radicals. It also modulates the levels of LPO and prominently increases the endogenous antioxidant enzyme levels in hepatocellular toxicity induced by carbon tetrachloride. The results obtained in this study suggest the preventive influence of moralbosteroid on liver toxicity in rats induced by carbon tetrachloride comparable with those of Silymarin.