High potential applications of nanocomposites of magnetic materials and metal-organic frameworks (MOFs) in drug delivery and cancer therapy

International Conference on Medical Physics

August 03-05, 2015 Birmingham, UK

Vahid Jabbari

Posters-Accepted Abstracts: J Nucl Med Radiat Ther

Abstract :

Metal-organic frameworks (MOFs) are new class of porous materials with high surface area and low density. Over past two decades, considerable advancements in MOFs preparation have been achieved, due to easily available raw materials and their high potential applications in adsorption, catalysis, gas storage, sensing, and biomedical applications. Regarding drug delivery and cancer therapy, it has been shown that, compared to conventional drug delivery systems, MOFs own great advantages to accomplish high drug loading and facile controlled drug release kinetics. However, in case of conventional drug delivery systems and MOF-based drug carriers, it is difficult to deliver drugs, drug get into blood before reaching targeting part. Magnetic-based drug delivery is versatile and efficient method to deliver drug to a specific location in body, which can be achieved by compositing magnetic material with drug. And through using an external magnetic field, conduction of magnetic particles and drug to a desired treatment location, is feasible, thus limiting spreading of drug to other parts of body and decreasing side effects of chemotherapy. Synergetic effect of magnetic materials-MOF composites offer advantages of high efficient drug loading and magnetically controllable drug delivery for potential applications in targeted drug delivery and cancer therapy.