Histopathological investigations on the effects of histidine and N-acetylcysteine on kidney lesions of rat induced by doxorubicin

19^th Global Nephrologists Annual Meeting

May 14-15, 2018 | Rome, Italy

Amir Abbas Farshid, Esmaeal Tamaddonfard and Sanam Mansouri

Urmia University, Iran

Posters & Accepted Abstracts: J Nephrol Ther

Abstract :

Male Wistar rats were divided into five groups of six rats each kept under standard experimental conditions. All the administrations were given intraperitoneally. Group I, received normal saline 1 ml/kg body weight for seven days. In group II, kidney lesions (congestion, hemorrhages and tubular degenerations and necrosis) induced by doxorubicin at the dose of 15 mg/kg body weight following normal saline administration for seven days. Rats in group III, given histidine 100 mg/Kg body weight for seven days followed by administration of doxorubicin and in group IV, N�acetylcysteine at the dose rate of 100 mg/Kg body weight given for seven days and followed by doxorubicin administration. In group V, both histidine and N-acetylcysteine were given for same period and the same dose levels prior to doxorubicin. The semi-quantitative histopathology results indicated that histidine and N-acetylcysteine when given alone could significantly only reduce the congestion but when given together had significant protective effects on all kidney lesions caused by doxorubicin.

Biography :

Amir Abbas Farshid is a Professor of Veterinary Pathology, Faculty of Veterinary Medicine, as well as Head of Electron Microscope Center, Urmia University, Urmia, Iran, with more than 85 research papers published in reputed journals.
Email:aa.farshid@urmia.ac.ir