Human bone tissue engineering

3^rd International Conference on Tissue Science & Regenerative Medicine

September 24-26, 2014 Valencia Convention Centre, Spain

L. Lee Chou

Keynote: J Tissue Sci Eng

Abstract :

T issue engineering by autologous osteoprogenitor cell transplantation with biodegradable and osteogenic materials has been used to regenerate human bone tissue in clinic. Several major breakthroughs have been made in this area: 1) Novel 3-D designs of the scaffolds offer a simultaneous control over macroscopic shape, oriented channels andmicroporosity to meet the distinct geometric requirements for the events of cell attachment, differentiation, vascularization, and new bone formation; 2) Novel composite materials possess programmed biodegradation and osteogenic bioactivity to regenerate bone tissue, as well as sufficient mechanical strength to maintain the shape of 3-D structures to guide bone formation; 3) State of the art fabrication methods proceedone step further to include both functionally graded materials and computer-designed 3Dgeometry to facilitate bone formation; 4) Delivery of autologous transplanted osteogeniccells meets functional requirements, technical feasibility and economic considerations. In vitro and in vivo studies have yielded significant data leading to successful clinical applications on selected challenging patients with severe bone defects

Biography :

L. Lee Chou, D.M.D., PhD, is a Professor of Biomaterials, Director of Molecular Biocompatibility Laboratory, Professor and Director of Oral Medicine, Goldman Schoolof Dental Medicine, Boston University