Human glia expresses cytoglobin after brain trauma

Annual Congress and Medicare Expo on Trauma & Critical Care

March 07-09, 2016 Madrid, Spain

Xiameng Chen

Sichuan University, P. R. China

Posters & Accepted Abstracts: J Trauma Treat

Abstract :

A 190-amino acid protein- Cytoglobin(Cygb), is a recently identified member of the vertebrate hemoglobin family. Cygb is an ancient and highly evolutionarily conserved protein. Like the other members of the hemoglobin family, functions of Cygb are mainly based on its oxygen binding ability. Cygb was previously demonstrated to be exclusively expressed by neurons of brain. However, a recent research reported the expression of Cygb in human GBM cells, hinting that glia cells may also express Cygb under certain pathological states. Therefore, to assess the cellular localization of human Cygb under physiological and pathological state, we performed immuno-staining to post-mortem brain specimens from people who died of traumatic brain injury and the deceased without neuropathy, respectively. In uninjured human brains, the immuno-signal of Cygb was restricted in neurons but not glia cells. Whereas in the chronic brain trauma group, expression of Cygb was also detected in astrocytes and microglia cells in the injury repairing area. Results of this present study offered the neuroanatomical basis for further exploration of the neuro-protective role of Cygb and suggested Cygb to be a novel therapeutic target in various neurological disorders.