Hypoglycemic, hypolipidemic and histological effects of ethylacetate extract of Combretum platypterum leaves in alloxan induced rats

15^th Annual European Pharma Congress

May 07-09, 2018 | Frankfurt, Germany

Fagbohun A B, Fred-Jaiyesimi A A, Sagamu, Nigeria Ndimele B E, Oluboba M A, James E S and Ibitoye S F

Olabisi Onabanjo University, Nigeria

Posters & Accepted Abstracts: Pharmaceut Reg Affairs

Abstract :

Statement of the Problem: Plants with medicinal properties are rich in phytochemical compounds. Some botanical polysaccharides have important bioactive components responsible for hypoglycemic effect, while some plants are known to have hypolipidemic activity. The purpose of this study is to determine the hypoglycemic, hypolipidemic and histological effects of ethylacetate extract of Combertum platypterum leaves in alloxan induced rats. Methodology & Theoretical Orientation: Sequential extraction was carried out on the plant leaves using n-Hexane, ethylacetate and methanol. These were concentrated to constant weights. Phytochemical screening was carried out on the crude sample of Combretum platypterum leaves. Diabetes was induced in the albino rats by the administration of alloxan monohydrate (150 mg/kg i.p.). The ethylacetate extract of Combretum platypterum at different doses of body weight were administered orally at a single dose per day to the diabetic induced rats for a period of 13 days. The effects of the ethylacetate extract of Combretum platypterum leaves and glibenclamide on blood glucose, plasma lipid and blood chemical parameters were measured in the diabetic rats. Histological effect of the ethylacetate extract of Combretum platypterum leaves was also carried on the liver, spleen, kidney and heart of the diabetic rats. Findings: Phytochemical screening showed the presence of flavonoids, saponins, cardiac glycosides, cyanogenetic glycosides, tannins and alkaloids, while anthraquinones were absent. Hypoglycemic effect of the ethylacetate extract of C. platypterum showed a significant positive effect. Administration of glibenclamide and the ethylacetate extract of C. platypterum showed significant hypolipidemic effect when compared with the reference range. This also caused reduction in total triglyceride and total cholesterol levels. Histological result showed that C. platypterum has no toxic effect on the organs. Conclusion & Significance: The ethylacetate extract of C. platypterum showed both hypoglycemic and hypolipidemic activities. Combretum platypterum has a great potential with activities to lead to desired drug design. ayodelefagbohun@yahoo.com