IKBKE promotes breast cancer metastasis through regulation of Snail

World Congress on Breast Cancer

August 03-05, 2015 Birmingham, UK

Jin Q Cheng, JianpingGuo, Qiang Huang, SrideviChalla and Domenico Coppola

H Lee Moffitt Cancer Center, USA

Posters-Accepted Abstracts: J Cancer Sci Ther

Abstract :

Metastasis is the most common cause of mortality in breast cancer.Epithelial-Mesenchymal Transition (EMT) and cancer stem cell are closely associated with breast cancer metastasis. Here we report that depletion of IKBKE markedly decreases invasion, EMT and cancer stem cell self-renewal as well as breast cancer growth and metastasis in MMTV-PyMT and orthotopic models. Furthermore, we demonstrated that IKBKE directly binds to and phosphorylates Snail.The phosphorylation led to stabilization and nuclear translocation of Snail, and increase of EMT and metastasis.Taken together, these findings indicate that IKBKE plays a pivotal role in metastasis and could be a critical therapeutic target for metastatic breast cancer.