Immunogenicity and safety of the vaccine combination CanigenTM DHPPi and NobivacTM L4 in dogs

7^th International Veterinary Congress

September 04-05, 2017 | Paris, France

Christelle Fontaine, Severine Arcidiaco, Therese Butaud, Joelle Cronier, Paul Schreiber and Sylvie Gueguen

VIRBAC, France

Posters & Accepted Abstracts: J Vet Sci Technol

Abstract :

Introduction: In order to benefit from the widest protection while keeping on a limited number and volume of vaccines administered, mixing of vaccines from different laboratories are commonly performed by veterinarians. The study aim was to confirm the safety and immunogenicity of the vaccines association CanigenTM DHPPi (Virbac) and NobivacTM L4 (MSD) in dogs. Methodology: Fifteen SPF male and female Beagle puppies of 9-10 weeks of age on Day 0 participated in this controlled randomized trial. Puppies, received two subcutaneous injections twenty-one days apart for the primary vaccination course. In group 1 (n=5), puppies received one dose of CanigenTM DHPPi vaccine rehydrated with one dose of NobivacTM L4 vaccine. Puppies belonging to group 2 (n=5) and group 3 (n=5) served as controlled and were vaccinated with respectively CanigenTM DHPPi/L and NobivacTM DHPPi (MSD) reconstituted with NobivacTM L4. Puppies were followed for forty-nine days for both, the appearance of any adverse reaction and seroconversion, assessed by either seroneutralisation assays or micro-agglutination tests. Statistical analysis were performed using Unistat 6.0 software. P<0.05 was considered as significant. Results: On Day 0, none of the puppies (n=0/15) had any antibody against the vaccines strains. After vaccination, no significant difference could be demonstrated between the groups regarding the antibody titres against the core vaccinal strains of CanigenTM vaccine and the Leptospira serovars of NobivacTM vaccine at the times of onset of immunity (Mann-Whitney U test, p>0.05). No general health parameter alteration or local injection site side effect was observed. Conclusion: CanigenTM DHPPi and NobivacTM L4 vaccines can be mixed and administered simultaneously to dogs without any major negative impact on the safety and immunogenicity of each respective vaccine.

Biography :

Christelle Fontaine is a Medical Manager, Companion Animals, Virbac. She is involved in phase IV trials and collaboration with universities and specialists across the world. She graduated from the French Veterinary School of Maison Alfort, in Paris in 2007.