Implant of autologous bone marrow mother stem cells in patients with congestive heart failure, functional class IV

7^th International Conference on Tissue Engineering & Regenerative Medicine

October 02-04, 2017 Barcelona, Spain

Fernandez Vina Matias, Fernandez Vina Roberto, Mart�­nez San Juan Federico, Fern�¡ndez Vina Federico, Camozzi Liliana and Saslavsky Jorge

Clinica San Nicol�¡s, Argentina

Scientific Tracks Abstracts: J Tissue Sci Eng

Abstract :

Objectives/Goals: The goals of the study are to: 1) Demonstrate that CD34+/CD38(-) adult stem cells in myocardial tissue generate a significant increase in the ejection fraction after implantation. 2) Observe the improvement in the quality of life of the implanted patients, evaluating the reduction of dyspnea and the number of hospitalizations. Material & Methods: A descriptive, observational study of 71 and 88-year-old patients with a history of CF IV heart failure with severe deteriorated FEY (<30%) who suffered hospitalizations every 15 days, due to biventricular dysfunction. They were submitted to implantation of bone marrow Stem Cells through retrograde venous technique in coronary sinus with balloon occlusion by femoral catheterization. A pre / post implant echocardiogram was indicated for comparisons (7 months) and a post-implant effort ergometry test was performed. Results: After a period of 210 days, a significant improvement in the ejection fraction of approximately 8% and 14% was observed with respect to the baseline (P:0.05), and a decrease in both hearts mass of 20% (grams). In addition, it was observed that the patients did not have recurrence in hospital admissions successively every 15-20 days, cause congestive heart failure and that there is a remarkable improvement in the quality of life rapidly after the implantation of stem cells. The post-implant ergometry test, at 210 days, turned out to be encouraging, since the patient tolerated the stress test greater than 6 minutes. Conclusion: The implantation of mother stem cells generated a favorable decrease in the number of hospital readmissions of the evaluated patients and showed improvement of their quality of life after no dyspnea CF IV. It was corroborated that there is a significant improvement of the ejection fraction, with decrease of the mass of implanted organ.

Biography :

Fernandez Viña Matias was educated at School of Medicine, Universidad Abierta Interamericana Rosario in 2014. He is a part of staff of Cardiology at Clinic San Nicolas and Professor at Universidad Abierta Interamericana.