Ekta Rawat and Ashu Chaudhary
Kurukshetra University, India
Scientific Tracks Abstracts: J Cancer Sci Ther
Despite many efforts, cancer is among the top three causes of death in modern society, demanding improved treatments, that currently includes surgery, chemotherapy, and various types of radiation therapy. Inorganic medicinal chemistry has been dominated by the study of the anti-cancer properties of macrocyclic metal complexes. There are a compelling number of drug targets where macrocycles have the potential to bind with good affinity. Metallomacrocycles is an outstanding tool for making structurally matching complexes with drastically different anticancer potentials. Macroyclic complexes possess a number of advantages that render them as attractive alternatives to organic small molecules for the development of therapeutic agents. In this perspective, we highlight recent advances in medicinal inorganic chemistry pertaining to the use of macrocyclic ligands for enhanced antimicrobial and anticancer activity. A novel series of macrocyclic complexes of Tin(II) have been derived from dicarboxilic acids and diamines. Characterizations were accomplished through elemental analyses, molecular weight determinations, infrared and multinuclear NMR studies to investigate their respective molecular structures. The spectral and computational studies are in good agreement with proposed framework of new complexes and supported an octahedral geometry around tin. The system described has been explored theoretically using molecular docking simulations. The complexes were screened against pathogenic fungi and bacterial strains. Some very active compounds were tested for anticancer activity against a panel of cell lines. The newly synthesized compounds displayed appreciable inhibitory potency in comparison with the standards.
Ekta Rawat is currently pursuingher PhD. in Bio-inorganic and SupramolecularChemistry at Kurukshetra University, India. She has been awarded with Young Scientist Award and Best Paper Presentation award at National conferences organised by reputed Universities of India. She has co-authored seven papers in Journals of International repute and one book chapter. She has presented papers in various International and domestic conferences. She has been awarded with the Fellowship by University Grants Commission; India in 2013. Moreover, she is also working on Major Research Project funded by UGC, Indiaon organometallic compounds in cancer therapy.She is also a life member of Indian Science Congress Association, Kolkata, India. One of her paper has been selected in 3rd Annual International Conference on Chemistry 2015 at Athens, Greece.Herresearch interests involve the development of some important biologically active metal based drugs.
Email: rawatekta24@gmail.com
Cancer Science & Therapy received 3968 citations as per Google Scholar report