In vitro cytocompatibility of the new bioalloy with superior performances in simulated extracellular fluids

3^rd International Conference and Exhibition on Materials Science & Engineering

October 06-08, 2014 Hilton San Antonio Airport, USA

P Drob, E Vasilescu, A Cimpean, S I Drob and C Vasilescu

Accepted Abstracts: Material Sci Eng

Abstract :

A new Ti-25Ta-5Zr alloy based only on non-toxic and non-allergic elements was elaborated in as-cast and thermomechanical processed states in order to be used as candidate material for implant applications. The new alloy has a microstructure with dendritic crystallites, till 200 μm in as-cast state and a more homogeneous microstructure with equiaxed β grains, till 50-70 μm, containing fine submicron acicular α phase in thermo-mechanical state. The interface between alloy and simulated extra-cellular fluids was characterized by a nobler, passive electrochemical behavior of the processed alloy than of the as-cast one, due to its finer microstructure obtained after thermo-mechanical treatment. Corrosion and ion release rates exhibited the lowest values for the recrystallized alloy as result of its more favorable microstructure. Impedance spectra denoted a more protective passive film. The processed alloy showed more electropositive values of its open circuit potentials, representing a better stability than the as-cast alloy. These potentials tended to more electropositive values in time, suggesting the strengthening of the processed alloy passive state. Scanning electron microscopy confirmed some depositions from solutions that contain calcium, phosphorous and oxygen ions (detected by energy dispersive X-ray analysis), namely calcium phosphate. In vitro tests performed on pre-osteoblastic MC3T3-E1 cells revealed that Ti-25Ta-5Zr alloy both in as-cast and recrystallized states exhibits good cytocompatibility and that thermo-mechanical treatment endows the alloy with superior biological performances in terms of cell adhesion and proliferation.

Biography :

P Drob has completed his PhD at the age of 30 years from ?Politehnica? University of Bucharest and postdoctoral studies from Institute of Physical Chemistry ?Ilie Murgulescu? of Romanian Academy. She is Senior Researcher at Institute of Physical Chemistry ?Ilie Murgulescu?, Bucharest, Romania. She has published more than 110 papers in reputed journals concerning the alloying elements effect on corrosion resistance of metallic biomaterials, passive film formation and their stability, corrosion and passivation mechanisms.