In vivo evaluation of poly (lactide-co-glycolide)/bioactive glass/hydroxyapatite nanocomposite coating in rabbit tibiae

2^nd International Conference and Exhibition on Materials Science & Engineering

October 07-09, 2013 Hampton Inn Tropicana, Las Vegas, NV, USA

Mehdi Mehdikhani-Nahrkhalaji

Accepted Abstracts: J Material Sci

Abstract :

The aim of this study was to evaluate the interaction of bioactive and biodegradable poly (lactide-co-glycolide)/bioactive glass/hydroxyapatite (PBGHA) nanocomposite coating with bone. Sol-gel derived 58S bioactive glass (BG) nanoparticles, 50/50 wt% poly (lactic acid)/poly (glycolic acid) (PLGA), and hydroxyapatite nanoparticles were used to prepare the coating. The nanocomposite coating was characterized by SEM, XRD, and AFM. Mechanical stability of the prepared nanocomposite coating was studied during intramed¬ullary implantation of coated Kirschner wires (k-wires) into rabbit tibiae. Titanium mini- screws coated with PBGHA nanocomposite coating was implanted intramedullary in rabbit tibia. Bone tissue interaction with the prepared nanocomposite coating was evaluated 30 and 60 days after surgery. Results showed that PBGHA nanocomposite coating remained stable on the K-wires with a minimum of 96% of the original coating mass. Tissue around the coated implants showed no adverse reactions to the coating. Woven and trabecular bone formation were observed around the coated samples with a minimum inflammatory reaction. It was concluded that PBGHA nanocomposite coating provides an ideal surface for bone formation and it could be used as a candidate for coating the orthopedic implants.

Biography :

Mehdi Mehdikhani-Nahrkhalaji has completed his Ph.D. at the age of 32 years from Isfahan University of Technology, Iran. He is the Assistant Professor at the Department of Materials and Metallurgical Engineering, Semnan University, Semnan, Iran. He has published several papers in reputed journals and serving as a reviewer of repute.