In vivo interaction studies of lisinopril with flurbiprofen and ibuprofen on carrageenan induced inflammation

3^rd International Conference and Exhibition on Biowaivers, Biologics & Biosimilars

October 27-29, 2014 Hyderabad International Convention Centre, Hyderabad, India

Safila Naveed, Najma Sultana and M Saeed Arayne

Accepted Abstracts: J Bioanal Biomed

Abstract :

Background: Both anti-hypertensive and non-steroidal anti-inflammatory drugs are frequently prescribed together because hypertension and musculoskeletal problems are two of the frequent conditions. Objectives: In vivo interaction studies of ACE inhibitor (Lisinopril) was carried out with commonly used NSAIDs flurbiprofen and ibuprofen in carrageenan induced inflammation (CII) rats to check the anti-inflammatory response of NSAIDs with lisinopril and alone. Methodology: In our study, the altered anti-inflammatory response was observed for NSAIDs when given simultaneously with lisinopril by comparing decrease in paw size. Results were expressed in % reduction in paw size for every hour and were calculated for edema rate and percentage reduction using the formula, Edema rate (E%)=VT-VO/VO*100 Where, VO=Rat?s hind paw volume before 1% Carrageenan administration and VT=Rat?s hind paw volume at t hour. Percentage reduction (R %)=EC-ET\EC*100 Where, EC=Edema rate of control group and ET=Edema rate of test compound at t hour. Results: The combination of lisinopril and NSAIDs showed decreased activity of NSAIDs as depicted by inhibition of % reduction and increase in edema rate. But since this study has certain limitation as a number of tested animals were small and the duration for which the anti-inflammatory response was checked for NSAIDs alone and in combination with ACE inhibitors was just few hours, further studies required to establish this relationship.