Intralesional Streptomycin: New, safe and effective therapeutic option for cutaneous leishmaniasis

20^th World Dermatology Congress

March 13-14, 2019 Singapore

Wisam Majeed Kattoof

Al-Mustansiriya University, Iraq

Scientific Tracks Abstracts: J Dermatol Dis

Abstract :

Introduction & Aim: Leishmaniasis encompasses a spectrum of chronic infections in humans in which organisms are found within phagolysosomes of mononuclear phagocytes. Cutaneous leishmaniasis is divided into Old World and New World, cutaneous leishmaniasis caused by L. tropica. Aminoglycosides which used in the first degree to treat infections caused by bacteria also tried as a new therapeutic option for parasitic infestation. Proliferation rate and protein synthesis in the promastigote stage of the parasite are inhibited by aminoglycoside like streptomycin. The main aim is to estimate the effectiveness of intralesional streptomycin as new antileishmanial agent.

Method: In total 46 patients involved with 109 lesions, 63 lesions (57.8%) were treated with intralesional injection of streptomycin after dilution with distilled water (20%) in group-1 and 46 lesions (42.2%) used as a control in group-2.

Results: In group-1 clinical cure was achieved in 40 lesions (83.3%). Moderate response was noticed in 8 lesions (16.7%). In group-2, none of the remaining 39 control lesions shows moderate, marked or total clearance degree of response. Only 3 lesions (7.7%) showed a slight degree of response and one lesion (2.7%) with mild degree.

Conclusion: Intralesional streptomycin 20% solution lead purpose of its use as new therapeutic option for skin lesions of leishmaniasis.

References:

1. Nameer K Al-Sudany and Yousif J Ali (2016) Intralesional 8.33% Rifamycin infiltration: New treatment for cutaneous leishmaniasis. Journal of Dermatology & Dermatologic Surgery; 20(1): 39-45.

2. Hamdi K I, Awad A H, Woker H M (2010) Evaluation of intralesional 0.2% ciprofloxacin as a treatment for cutaneous leishmaniasis. East Mediterr Health; 1(16): 89-93.

Biography :

Wisam Majeed Kattoof has his expertise in evaluation and passion in improving the health and wellbeing. His open and contextual evaluation model based on responsive constructivists creates new pathways for improving healthcare. He has built this model after years of experience in research, evaluation, teaching and administration both in hospital and education institutions.

E-mail: wissammajeed200@yahoo.com