Lower annual cardiac events in diabetics with a normal exercise GMPI and a functional capacity 7 METS on treadmill

5^th World Heart and Brain Conference

September 24-26, 2018 Abu Dhabi, UAE

Nosheen Fatima and Maseeh uz Zaman

Aga Khan University Hospital, Pakistan
Karachi Institute of Heart Diseases, Pakistan

Posters & Accepted Abstracts: J Cardiovasc Dis Diagn

Abstract :

Background & Aim: Good exercise capacity has a high Negative Predictive Value (NPV) in patients with known or suspected Coronary Artery Disease (CAD) similar to a normal Gated Myocardial Perfusion Imaging (GMPI). The aim of this study was to evaluate NPV of functional capacity during treadmill exercise in diabetics with normal GMPI in Pakistani population. Method: This was a prospective study which included 338 diabetics with normal exercise GMPI at Karachi Institute of Heart Diseases from June 2014 till June 2016. On the basis of Metabolic Equivalents (METS) achieved during exercise, these patient were divided into Group A: â�¥7 METS (140 patients) and Group B: <7METS (198 patients). These patients were followed up on telephone (for 18�±3 months) for fatal or non-fatal myocardial infarction (FMI and NFMI, respectively). Regarding risk factors in Group A and B, like obesity (50 vs. 54%), hypertension (61 vs. 60%), smoking (14 vs. 15%), dyslipidemia (32 vs. 42%) and family history (32 vs. 30%), no significant difference was found. Result: The mean age predicted HR (MAPHR) achieved in group was significantly higher than Group B (86% vs. 83%). No significant difference was found between LV functional parameters (like ejection fraction, end diastolic and systolic volumes) of two groups. During follow up period, the overall all cardiac events reported in Group A was 03 (all NFMI and no FMI) while in Group B 16 events (15 NFMI and 01 FMI) were reported. Annualized event rate for overall events, NFMI and FMI in two groups were 1.43 vs. 5.39%, 1.43 vs. 5.05 and 0% vs. 0.3%, respectively. Conclusion: We concluded that NPV of a normal GMPI is higher in diabetic patients with a functional capacityâ�¥7METS than their counterparts who could achieve<7METS on treadmill.

Biography :

E-mail: nosheen.fatima@aku.edu