Lymhoepithelioma-like carcinoma of the uterine cervix-association with Epstein-Barr virus and human papillomavirus

12^th World Cancer Conference

September 26-28, 2016 London, UK

Angel Danchev Yordanov, Dimitrova B I, Betova T M, Karcheva M D and Trifonov R G

UMHAT â�?�?Doctor Georgi Stranskiâ�?-Pleven, Bulgaria
Medical University Pleven, Bulgaria

Scientific Tracks Abstracts: J Cancer Sci Ther

Abstract :

Introduction: Lymphoepithelioma-like carcinoma (LELC) of the uterine cervix is a rare variant of squamous cell carcinoma (SSC). It differs from the usual SSC of the cervix in its morphology and clinical behavior and shows a better prognosis than the more common SSC of the cervix. It is associated with EBV infection in Asian women and with HPV or no infection in Caucasian patients. Aim: Our aim is to confirm whether or not LELC is more common in Caucasian patients with EBV/HPV infection or whether there is no correlation to the previous viral exposure. We try to link the viral status with the survival rate and the prognosis. Materials & Methods: A retrospective research has been done on 775 female patients for a period of 8 years, who have been operated for cervical cancer in the Oncogynecological Department of UMHAT â�?�?Doctor Georgi Stranskiâ�?-Pleven. A group of 16 women with LELC have been identified by clinical data. Morphologically the patients have been examined routine-histologically and immunohistochemically, for assessment of the viral status, with monoclonal antibodies against EBV/HPV by DAKO protocol. Results: Three of the women have been proven to have EBV and one-HPV infection. In the other cases no viral infections have been identified. Conclusion: Our results show a stronger correlation between LELC in Caucasian women and a previous EBV infection or no viral infection, rather than association with HPV infection. This data is very different from the previous research that has been done on this topic.

Biography :

Yordanov A D has completed his graduation from Medical University-Sofia in 2003. In 2009, he became a Specialist in Obstetrics in Gynecology. Since then he has been working in Oncogynecology Department-UMHAT “Doctor Georgi Stranski”-Pleven. He also works as an Assistant in Medical University-Pleven. His interests are in the field of Operative Oncogynecology. He has several publications in various magazines.

Email: angel.jordanov@gmail.com