Magnetic nanoparticle hyperthermia for deep sitting cancer therapy

International Conference on Medical Physics

August 03-05, 2015 Birmingham, UK

Fridon Shubitidze

Posters-Accepted Abstracts: J Nucl Med Radiat Ther

Abstract :

Magnetic nano-particle hyperthermia (MNPH) is minimally invasive thermal technique for cancer therapy. One of main characteristics of MNPs for clinical hyperthermia is a high specific absorption rate (SAR), which depends on the applied magnetic field frequency, strength and MNP properties. During MNPH therapy a coil produces alternating electric and magnetic fields. The alternating magnetic field (AMF) penetrates inside tissue and activates MNPs in cancerous tissues, where else the alternating electric field produce undesirable eddy currents within normal tissue. Since, the AMF from a coil decays rapidly (as 1/R2); therefore, to use magnetic hyperthermia for deep tumors, such as pancreatic, prostate, rectum and etc. cancers, a high-magnitude transmitter current is required in the coil. High transmitter currents also produce high electric fields E and eddy currents J within normal tissue that cause non-specific heating (J.E), which limits the applicability of MNP hyperthermia for deep sitting cancers. To overcome this problem, recently we have develop next generation Dartmouth MNP, with high SAR at low AMF strength, and a new device for guiding and delivering transmitted magnetic fields to deep tumors and for minimizing undesirable eddy currents heating in normal tissues. In this presentation, first the systemâ??s AMF delivery and focusing performance will be described and illustrated using both modelled and measured data, then temperature distributions in a conducting phantom with and without the flexible magnetic device will be shown, and finally, applicability of the device for clinically MNPH therapy will be demonstrated in combination with the next generation MNP.