Mechanism of myocardial damage cardiac cell therapy and its trials cell-derived bio medicals strategies to promote cardio-myocyte proliferation optimization of medical therapy and left ventricular assist device conclusio

31^st International Conference on Clinical and Experimental Cardiology & 3^rd Annual Summit on Cardiology and Heart Diseases

September 21, 2022 | Webinar

Sameh Hozayen

Assistant Professor of Medicine, University of Minnesota

Keynote: J Cardiovasc Dis Diagn

Abstract :

Definition Broad effort that aims to repair irreversibly damaged heart tissue with cutting edge science including stem cell and cell free therapy Mechanism of myocardial damageCardiac Cell therapy and its trials c-kit positive cells (CPCs) Stimulate paracrine mechanisms by reducing inflammation, fibrosis, and apoptosis Promote angiogenesis. Bone marrow drive mesenchymal stromal cells (MSC) Cardiac microvascular networks, and a reversal of endothelial dysfunction Cardiac Cell therapy and its trials. DREAM-HF trial 565 patients received end ventricular injections of allogeneic MSCs or placebo Missed primary heart failure endpoints Reduction of major adverse cardiovascular events (MACE) fatal and nonfatal myocardial infarctions (MI) (Johnston et al). Cardiac Cell therapy and its trials Concrete Heart Failure 125 patients were randomized to trans-endocardial injection of both MSCs and CPCs, MSCs alone, CPCs alone, or placebo. Significant difference in HF-MACE (defined as all-cause death, hospitalization for worsening HF, or HF exacerbation not requiring hospitalization) lowest in patients who received CPCs alone driven primarily by reduction of HF hospitalization and improved quality of life as assessed by the Minnesota Living with heart failure questionnaire No significant differences in left ventricular ejection fraction (LVEF), myocardial scar size, or 6-minute walk test (Bolli et al) Cell-derived biomedicals. Human Pluripotent stem cell (PSC) Embryonic stem cells Induced pluripotent stem cells Cell sheet in a successful case report (Miyagawa et al) Collagen-based construct in BioVAT-HF (Tiburcy et al)

Biography :

I am a cardiologist by training and a hospitalist by trade. I patented technology in diagnostic modules complimentary to ventricular assist devices, and published and presented multiple papers and abstracts in cardiovascular medicine specifically heart failure, both in Egypt, my home country, and the USA. I am currently a faculty of internal medicine and inpatient medicine at the University of Minnesota, USA.