Mesothelioma mimics

International Conference and Exhibition on Lung Disorders & Therapeutics

July 13-15, 2015 Baltimore, Maryland, USA

Hasleton P S

Posters-Accepted Abstracts: J Pulm Respir Med

Abstract :

The histological diagnosis of pleural mesothelioma can be very challenging to the histopathologist. Separation of benign from malignant pleural disease is one the most difficult areas in pleural pathology and this topic will be considered. In 22% of 217 cases coming to the US and Canadian Mesothelioma Panel, there was disagreement between one or more panelists as to whether a case was mesothelioma or benign. Mesothelioma has three subtypes such as epithelioid, sarcomatoid (including desmoplastic) and biphasic. The differential diagnosis will therefore be considered in these three categories with demonstration of how to separate the entities. The diagnosis of mesothelioma requires full clinico-radiological-pathological correlation, the availability of adequate samples for the histopathologist, including the parietal pleura, which can provide helpful pointers and the use of special stains, including immunocytochemistry. However special stains have their limitations, as will be shown.