Metalorganic magnetic nanoparticles as a targeted drug delivery system of Gd3+ ions for neutron-capture therapy against cancer

2^nd International Conference and Exhibition on Materials Science & Engineering

October 07-09, 2013 Hampton Inn Tropicana, Las Vegas, NV, USA

Olga Vladimirovna Kondrashina

Accepted Abstracts: J Material Sci

Abstract :

The challenge in successful neutron-capture therapy against cancer has been the ability to keep proper concentration of Gd in tumor tissues during the irradiation. We developed a new method of producing nanoparticles based on cholesteric liquid crystal DNA-dispersion complexed with Gd in very high local concentration of gadolinium ions (up to 400 mg/ml inside particles). Their magnetic properties lead to active diffusion of Gd in tissue with the help of a strong magnetic field and keep those nanoparticles there for the desired amount of time. Due to the high local concentration of gadolinium, the impact of irradiation of the neutron-capture therapy occurs very locally (radius of influence is around 100 microns from particle) but highly effective and that preserves the healthy tissues from unwilling damage. One more potential way found was to actively target delivery of gadolinium ions in tumors. That is immobilization of nanoparticles by adsorption on macrophages. This way may help irradiate malignant cells within ascite tumors. The composition can be stored in the laboratory for 200 days without any change in physical properties. These nanoparticles have a great affinity to gadolinium ions, so have low toxic effect on living cells without irradiatio

Biography :

Olga Vladimirovna Kondrashina, Ph.D. is science researcher in Voronezh State University, Russia. Her research interest is focused on nanoparticle for Gd neutron-capture therapy of malignant tumors. She has several publications in collaboration with Russian Academy of Science concerning use of cholesteric liquid crystalline dispersion from DNA as a raw material for nanoparticle manufacturing and some publication together with All-Russian Institute of Medicinal and Aromatic Plants (VILAR) concerning development of nanotechnology drug delivery system for targeting drug directly into injured tissues.