Metaplastic breast carcinoma: A single center experience in Pakistan

3^rd World Congress on Women’s Health & Breast Cancer

October 03-05, 2016 London, UK

Zarka Samoon, Adnan Abdul Jabbar, Madiha Beg and Romana Idrees

Aga Khan University Hospital, Pakistan

Scientific Tracks Abstracts: J Cancer Sci Ther

Abstract :

Introduction: Metaplastic breast carcinoma (MBC) is a rare disease with an incidence of <1%. In comparison to invasive ductal carcinomas (IDC), MBC present with a larger tumor size, few nodes involved, mostly high grade and triple negative, and with a shorter overall survival. Aim: Aim of this study is to determine the progression free and overall survival of patients with MBC. Methods: From July 2006 till June 2013, 32 patients with MBC treated at Aga Khan University Hospital, Karachi were identified and retrospectively reviewed. Kaplan-Meier method was used for survival analysis. Results: Prevalence of MBC was 1.92% among breast cancer patients. The median age at tumor diagnosis was 54 years. 29 (90.6%) patients had grade III tumor. The most common histopathology was squamous (65.6%) followed by spindle (12.5%) and carcinosarcoma (9.4%). Median tumor size was 4.5 cm. 17 (53.1%) patients had nodal involvement. Two patients (6.2%) had metastatic disease at presentation. Hormone receptors were positive in 16 (50%) patients and negative in 15 (46.9%) patients. HER-2 neu receptor was positive in three (9.4%) patients. 27 (84.4%) patients underwent modified radical mastectomy. Neoadjuvant and adjuvant chemotherapy (anthracycline based in most cases) was received by 10 (31.25%) and 15 (46.8%) patients respectively. The median progression free and overall survival was 26 months and 27 months respectively. Five year progression free and overall survival was 72% and 73% respectively. Conclusion: Our patients had tumors which were mostly high grade, large, with around half of them having nodal and hormonal involvement with better survival outcomes compared to series described earlier.

Biography :

Zarka Samoon has completed her MBBS, followed by MRCP in Medicine and MRCP in Medical Oncology. She is a Medical Oncology Faculty at Aga Khan University Hospital with keen interest in Breast and Female Genital Tract Malignancies.

Email: zarka.samoon@aku.edu