Micellar Solubilization in the formulation development of poorly soluble Naproxen

2^nd International Conference and Exhibition on Pharmaceutical Regulatory Affairs

November 23-24, 2012 Hyderabad International Convention Centre, India

P. Durga Maheswari, D. Rambhau., M. Laxmi Narasu and Mitrabhanu Mohanty

Posters: Pharmaceut Reg Affairs

Abstract :

In the present research work, micellar solubilization technology has been employed for the formulation development of poorly soluble Naproxen and evaluation was done basing upon the dissolution study. Naproxen, an arylacetic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs) has analgesic and antipyretic properties used for the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, tendinitis, bursitis, and acute gout. Micellar solubilization technology has been employed for increasing the solubility of the poorly soluble NSAID. Cloud Point Temperature (CPT) of the nonionic surfactants has been used as the basis for the solubility study because there is better entrapment of the drug into the surfactant micelle at this temperature. The results of dissolution study of spray dried formulation reveal the pH independent solubility enhancement of Naproxen. The characterization study with particle size and size distribution, scanning electron microscopy, fourier transform infrared spectroscopy, differential scanning calorimetry and X-ray powder diffractometry also reflect the compatibility of the drug with the excipients and the morphological characteristics of the drug and spray dried powder. Thus, the micellar solubilization at CPT has been identified as one of the most efficient method of solubility enhancement, consequently spray drying of micellar solution to improve wettability, solubility and hence the dissolution behaviour of poorly soluble drugs.

Biography :

P. D. Maheswari is pursuing Ph.D. entitled "Formulations of poorly water soluble drugs using micellar solubilization technology", from Jawaharlal Nehru Technological University, Hyderabad, AP, INDIA. She had completed M. Pharm in Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam, A.P, INDIA. She is working as Senior Manager, Formulation Research & Development, Natco Research Center, Sanathnagar Hyderabad.