Microenvironment of morphologic structures of invasive carcinoma NST

International Conference and Exhibition on Molecular Medicine and Diagnostics

August 24-26, 2015 London, UK

Liubov A Tashireva

Posters-Accepted Abstracts: J Mol Genet Med

Abstract :

Invasive carcinoma of non-specific type (IC NST) is characterized by different morphological structures presence. These structures
are divided into two subtypes. The first group includes tubular, trabecular structure and discrete tumor cells and is characterized
association of tumor cells not only with other tumor cells, but with the stroma. The second group, which includes solid and alveolar
structure characterized connections between tumor cells without any connection with the stroma excepting external layer of cells.
Significance of morphological intratumoral heterogeneity of IC NST described for tumor progression dependent on the menstrual
status of patients. Furthermore, our research team demonstrated that the presence of alveolar structures increases the risk of nodal
metastasis of IC NST. However, until now the role of the microenvironment of various structures in tumor progression is unknown.
Gene expressions analyze shows heterogeneity of microenvironment of morphological structures of IC NST. The microenvironment
of alveolar structures presented Th2-type immune response. Since the property of the tumor microenvironment is closely interacting
with tumor progression, it can be concluded that the development of Th2 immune response in microenvironment of alveolar
structures contributes to the manifestation its invasive properties.

Biography :

Liubov A Tashireva has completed her PhD from Siberian State Medical University. She is the Research Fellow of pathological anatomy department of Tomsk Cancer
Research Institute. She has published more than 9 papers in reputed journals.