MicroRNAs from dietary sources hold potential role in restoring tumor suppressor function

32^nd Euro Congress on Cancer Science & Therapy

March 07-08, 2019 | Barcelona, Spain

Shaikh Mohd Inayatullah, Afzal Ansari, Garima Ayachit, Priyanka Sharma, Chaitanya G Joshi and Jayashankar Das

Gujarat Biotechnology Research Centre, India

Posters & Accepted Abstracts: J Cancer Sci Ther

Abstract :

MicroRNAs (miRNA) are well known for their role in epigenetic regulation and any alteration in their regulatory cascade disrupts the whole network, thereby triggering a diseased condition. Discovery of exogenous plant microRNAs in humans forms a crucial base for understanding cross-kingdom gene regulation and open the doors to explore its therapeutic potential in multiple diseases like cancer. In the present study, role of miRNAs from eight fruit sources were analyzed in human disease regulatory network. A total 893 dietary derived miRNAs were screened, of which 291 miRNAs, show functional homology with 163 human miRNAs. Disease association analysis showed that, 13 of 163 miRNAs have association with multiple diseases including prevalent cancers of breast, lung, head, pancreas and prostate. These miRNAs generally act as a tumor suppressor in healthy cells, but get deregulated in cancer cells. Hence, their tumor suppressor activity in cancer cells may be restored by replacing with their functional homologs from dietary sources. In conclusion, our findings suggests that, dietary miRNAs may be used as substitutes in cancerous cells, and act as a suppressor for restoring normal functions of the cell. Therefore, miRNA derived from dietary sources will be the thrust area of future research and will help in developing new molecular therapeutics approaches such as �??miRNA replacement therapy�?� in cancer management.

Biography :

E-mail: inayat45shaikh@gmail.com