Mitochondria“The el dorado”in cancer?

2^nd International Conference and Exhibition on Pharmaceutical Regulatory Affairs

November 23-24, 2012 Hyderabad International Convention Centre, India

Teegala Suraj Benarji

Accepted Abstracts: Pharmaceut Reg Affairs

Abstract :

The present topic under discussion owes its credibility to the ?WARBURGS EFFECT? and the subsequent findings that state the behaviour of the tumor cells towards their process of energy generation when compared with normal cells which usually rely upon the energy releasing pathways viz. GLYCOLYSIS and OXIDATIVE PHOSPHORYLATION. The tumor cells unlike the normal cells up regulate the process of glycolysis even under aerobic conditions to meet their energy demands and there is ample room for an insight into the possible mechanisms responsible for the up regulation of the glycolytic pathway and compromise of the mitochondrial functions. The past decade has also witnessed the role of Mitochondria in APOPTOSIS( Programmed Cell Death) by the intrinsic and extrinsic mechanisms involving the CASPASES. This topic discusses the imbalance between the pro apoptotic and anti-apoptotic proteins viz. Bcl-2 and Bax in tumors and the role of p53, HIF-1(HYPOXIA INDUCIBLE FACTOR-1 that plays a role in up regulating the enzymes pyruvate dehydrogenase and lactate dehydrogenase in tumor cells ) in the shift of energy releasing pathway from oxidative phosphorylation to glycolysis and how the shift could affect the outer mitochondrial membrane, that plays a crucial role in triggering apoptosis. Owing to the finding in the past years, thorough insight into the role of Mitochondria in cancers could aid in serving as a source for promising targets that can shift the energy pathway from glycolysis and stimulate the silent or suppressed apoptotic pathways.

Biography :

T. Jayaprakash has completed his B.pharm in Sri Siddhartha Pharmacy College, Nuzvid affiliated to Acharya Nagarjuna University, Guntur. He has qualified in GPAT-2011. Now he is doing his M.paharm with pharmacology specialization in Jawaharlal Nehru technological University, Kakinada. His areas of interest are Regulatory affairs, Research & Development, Pre-clinical studies.