Modification of Mg-doped fluoridated hydroxyapatite nanoparticles by amino acids as a drug delivering nanobio-polymer composite for tissue engineering

International Conference and Expo on Ceramics

August 17-18, 2015 Chicago, USA

Zeinab Fereshteh

Scientific Tracks Abstracts: J Material Sci Eng

Abstract :

In the past few years, hydroxyapatite (HA) has been widely used as a bioactive ceramic. Not only does the development of modified-
HA by the substitution of Ca ions and OH groups make its chemical composition similar to that of the natural bone tissue, but also
improves the in vitro behavior of commercially synthesized HA. Aiming at such capabilities, magnesium-fluoridated hydroxyapatite
nanoparticles (Mg-FHA NPs) have been recently developed. But, NPs have high surface energy and therefore, they cannot be
well dispersed in a bio-polymer matrix to prepare a polymer/ceramic composite, which is usually required for tissue engineering
applications. To resolve this problem, we aimed to modify the surface of Mg-FHA NPs using a few well-known natural amino
acids as the cost-effective and environment-friendly bio-materials. As coupling agents, L-leucine, L-isoleucine, L-methionine,
L-phenylalanine, L-tyrosine and L-valine amino acids were employed and by performing the sonication technique the surface
Mg-FHA NPs was modified. The results confirmed that using amino acid molecules led to uniform dispersion of Mg-FHA NPs
in the organic environment by making the surface of NPs hydrophobic, although the length and chemical reactivity of amino
acid molecules affected the efficiency of NPs dispersion. The uniform distribution of Mg-FHA NPs could be regarded as a desired
condition for polymer/ceramic composite preparation with high applicability for biomedical purposes.

Biography :

Zeinab Fereshteh has completed her PhD from Isfahan University of Technology. She is an Assistant Professor at the Institute of Science, High Technology, and
Environmental Sciences, Graduate University of Advanced Technology. She has published more than 15 papers in peer-reviewed journals and presented/attended
more than 10 conferences in the nano-materials and nano bio-materials fields.