Maha Z Rizk
National Research center, Egypt
Posters-Accepted Abstracts: J Mol Biomark Diagn
Hypercholesterolemia (HC) is frequently associated with oxidative stress, and release of inflammatory cytokines. The objective of this study is to determine the hypolipidemic effects of sulphated polysaccharides from the seaweed Ulva fasciata algal extracts (UFP) through measuring certain biomarkers related to liver and kidney functions in hypercholesterolemic as compared to normal rat serum. Rats were fed high-fat diet with oral cholesterol administration. Total lipid profile, liver and kidney functions, inflammatory cytokines (TNF-�±, CRP, MPO and IL-10), oxidative stress markers (GSH, MDA and NO), and cell adhesion molecules (ICAM-1 and VCAM-1), were assessed before and after treatment with UFP. Histological examination of heart, liver and kidney were performed and revealed increased cholesterol, triglycerides, LDL, oxidative stress and inflammatory markers in HC-rats. Histopathological examination of heart aorta revealed obvious fatty plaques and that of liver demonstrated severe degeneration of liver cells, necrosis and presence of fatty droplets. In addition, nephron-histological examination showed mild glomerular injury, vascular and inflammatory changes. Treatment with UFP effectively reduced the number and intensity of heart plaques, diminished formation of fatty liver, as well as improved hepatic and renal function as compared to the reference drug; fluvastatin. It could be concluded that consumption of UFP may be beneficial in amelioration of biomarkers related to hypercholesterolemia disorders; such as obesity and heart injury, hence reduce the possibility of heart strokes in hypercholesterolemic patients.
Email: maha_zaki_rizk@yahoo.com
Molecular Biomarkers & Diagnosis received 2054 citations as per Google Scholar report
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