Pravin D Potdar
Posters Accepted Abstracts: J Cancer Sci Ther
Cancer Stem Cells (CSCs) are mainly found in tumors at very low concentration and have the similar properties of normal stem cells. These cells have a property of self renewal & differentiation. However, the renewed cells are found to be tumorogenic in nature. These cells are also very much resistant to chemotherapies and radiotherapies. This may be the major mechanism involved in the relapse & metastasis of tumor cells at different site of human body. However, the origins of CSCs are not yet known clearly. Recently our study on Breast Cancer Stem Cells have shown that CSCs are very few in number and there is a probability of transferring cancer phenotype of these cells to neighboring normal cells to make normal adjacent cells to cancer cells. This results into formation of metastatic tumor which is resistant to general chemo or radiotherapies. So there is a need to establish a method to isolate these CSCs from the tumor of the patient by growing them in culture or any other fractionation method by using specific cancer antibodies. The isolated CSCs are then profiled by using several Molecular Markers involved in Cancer development. Differential expressions of these markers can be used as biomarkers to target CSCs present in patient tumor or in blood circulation during metastasis. Advancement in nanotechnology will help in delivering this specific bio-molecule to target CSCs without harming normal stem cells. This will have a great advantage to overcome several side effects caused by the present therapies of cancers. The strategies of targeting CSCs can also be useful in early diagnosed cancer as well as the cancer with severe metastasis to distant organs. This presentation will overview various strategies so far established in development of targeted therapies of cancers by eradicating cancer stem cells.
Cancer Science & Therapy received 3968 citations as per Google Scholar report
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