Multi-detector computed tomography (MDCT) findings of chemotherapy induced hepatic changes

8^th Euro Global Summit on Cancer Therapy

November 03-05, 2015 Valencia, Spain

Adel El-Badrawy

Faculty of Medicine and Oncology Center- Mansoura University, Egypt

Posters-Accepted Abstracts: J Cancer Sci Ther

Abstract :

Purpose: to evaluate the role of multi-detector computed tomography (MDCT) in detection& characterization of chemotherapy induced hepatic changes. Materials and methods: This retrospective study included 400 patients with confirmed 15 malignancies and treated by standard chemotherapy regimens. The most common malignancy was non Hodgkin lymphoma and mostly chemotherapy regimen was Cyclophosphamide, Hydroxydaunomycin, Oncovin and Prednisolone (CHOP). All patients underwent CT scan using 64 MDCT scanner (Brilliance 64, Philips) before chemotherapy and follow up after 6 months from last session of chemotherapy. Pre contrast series and post-contrast triphasic study were done for all patients. All the patients underwent radiological evaluation for hepatic changes after chemotherapy treatment. All CT scans were evaluated for fatty liver, capsular retraction, ascites, veno-occlusive disease and biliary sclerosis. Four patients with capsular retraction underwent liver biopsy. Results: Forty patients (32 females and 8 males) had hepatic changes due to effect of chemotherapy. The most common CT finding was fatty liver. Hepatic fatty changes detected in 36/40 patients. These fatty changes were diffuse, focal fatty and diffuse with fatty spare area in 31, 3 and 2 cases respectively. Four patients had capsular retraction; 1 patient with HD and 3 patients with metastatic cancer breast. Veno-occlusive disease and biliary sclerosis were not detected. Conclusion: MDCT can accurately detect and evaluate chemotherapy induced hepatic changes, differentiation of these changes from progression of the disease and/or super added pathology. Fatty liver is the commonest hepatic induced changes. Clinical application: Awareness of chemotherapy induced hepatic changes can help the radiologist to detect these at early stages, which helps in appropriate management.

Biography :

Email: biotiquin@gmail.com