Nanoencapsulated phytochemicals based gold nanoparticles and their application in nanomedicine

3^rd International Conference and Exhibition on Materials Science & Engineering

October 06-08, 2014 Hilton San Antonio Airport, USA

Menka Khoobchandani, Kavita Katti and Kattesh V Katti

Accepted Abstracts: Material Sci Eng

Abstract :

Nanotechnology based therapeutics and imaging represent a new platform for treatment and diagnostics. Despite the versatility of nanomedicine based therapies, it is important to develop the cost effective nanoparticles with more efficacy and less side effect. Our laboratory focuses on the Green Nanotechnology, where we develop the nanoparticles from naturally occurring phytochemicals. Nanoencapsulation of phytochemicals based formulations has shown great promise in enhancing drug efficacy, increasing drug tolerance, and improving targeted drug delivery. Among the other, gold nanoparticles possess a tremendous opportunities for the next generation bio-agent. Herein, we comprehensively develop the nanoparticles from phytoextract and their phytochemicals by simple mixing with gold salt. We explored the synthesis and characterization of phytoextract and their phytochemicals based gold nanoparticles and their anticancer activity against metastatic breast and prostate cancer cell line and their cellular internalization. We have explored various plant extract like broccoli, tea leaves, and mango peel. These plant extracts showed the presence of most promising phytochemicals like mangiferin in mango peel, isothiocyantes and glucosinolates in broccoli and EGCG in green tea. The synthesis of phytochemicals conjugated nanoparticles was confirmed by various spectroscopic techniques like UV visible, transmission electron microscope, atomic absorption spectrometry, and the size was confirmed by dynamic light scattering instrument. We showed that nanoparticles treatment resulted in decreased cell viability and suppression of metastatic potential in terms of migration and invasion in metastatic cancer cells. Among the other, mangiferin conjugated nanoparticles induce down regulation of NFkB factor and induce apoptosis in the cancerous cells. These findings suggest that phyto chemicals based gold nano particles might be a very promising candidate for cancer intervention and prevention.

Biography :

Menka Khoobchandani has completed her PhD at the age of 26 years from Dayalbagh Educational Institute, Dayalbagh, Agra, India. She is a Postdoctoral researcher at Department of Radiology and Cardiovascular Medicine, University of Missouri, Columbia, MO, USA. She has published more than 10 papers in reputed journals and presentation to her credit. She has filled one patent through a recent discovery on Cardiotherapeutic nanopharmaceuticals - A new alternative to drug coated stents.